Article
Spectrum of PALB2 germline mutations and characteristics of PALB2-related breast cancer: Screening of 16,501 unselected patients with breast cancer and 5890 controls by next-generation sequencing.
Cancer - 15 Jul 2020
Zhou Jiaojiao, Wang Honglian, Fu Fangmeng, Li Zhanwen, Feng Qingjian, Wu Weizhu, Liu Yun, Wang Chuan, Chen Yiding
Abstract excerpt
BACKGROUND: Partner and localizer BRCA2 (PALB2) is a breast cancer predisposition gene, but the clinical relevance of PALB2 germline mutations in Chinese patients with breast cancer remains unknown. This study attempted to investigate the full prevalence and spectrum of PALB2 germline mutations in China and the associations between PALB2 germline mutations and breast cancer risk. METHODS: A total of 21,216...
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