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Article

Endogenous Rab38 regulates LRRK2's membrane recruitment and substrate Rab phosphorylation in melanocytes.

The Journal of biological chemistry - 1 Oct 2023

Unapanta Alexandra, Shavarebi Farbod, Porath Jacob, Shen Yiyi, Balen Carson, Nguyen Albert, Tseng Josh, Leong Weng Si, Liu Michelle, Lis Pawel, Di Pietro Santiago M, Hiniker Annie

Abstract excerpt

Point mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson's disease and augment LRRK2's kinase activity. However, cellular pathways that endogenously enhance LRRK2 kinase function have not been identified. While overexpressed Rab29 draws LRRK2 to Golgi membranes to increase LRRK2 kinase activity, there is little evidence that endogenous Rab29 performs this function under physiological conditions....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

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Source

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Identifiers

PMID: 37625589
DOI: 10.1016/j.jbc.2023.105192
PMCID: PMC10551901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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