Article
Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes.
The Journal of cell biology - 23 Oct 2006
Wasmeier Christina, Romao Maryse, Plowright Lynn, Bennett Dorothy C, Raposo Graça, Seabra Miguel C
Abstract excerpt
A mutation in the small GTPase Rab38 gives rise to the mouse coat color phenotype "chocolate" (cht), implicating Rab38 in the regulation of melanogenesis. However, its role remains poorly characterized. We report that cht Rab38(G19V) is inactive and that the nearly normal pigmentation in cht melanocytes results from functional compensation by the closely related Rab32. In cht cells treated with Rab32-specific...
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