Article

Distinct roles for RAB10 and RAB29 in pathogenic LRRK2-mediated endolysosomal trafficking alterations

2020-06-20

Abstract excerpt

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) cause familial Parkinson’s disease, and sequence variations are associated with the sporadic form of the disease. LRRK2 phosphorylates a subset of RAB proteins implicated in secretory and recycling trafficking pathways, including RAB8A and RAB10. Another RAB protein, RAB29, has been reported to recruit LRRK2 to the Golgi where it stimulates its ki...

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Literature Corpus work: eefc48b5-f2ba-5c74-8832-4bd89fdd8a6b
DOI: 10.1101/2020.06.20.163063

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