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Article

The emerging role of SPOP protein in tumorigenesis and cancer therapy.

Molecular cancer - 4 Jan 2020

Song Yizuo, Xu Yichi, Pan Chunyu, Yan Linzhi, Wang Zhi-Wei, Zhu Xueqiong

Abstract excerpt

The nuclear speckle-type pox virus and zinc finger (POZ) protein (SPOP), a representative substrate-recognition subunit of the cullin-RING E3 ligase, has been characterized to play a dual role in tumorigenesis and cancer progression. Numerous studies have determined that SPOP suppresses tumorigenesis in a variety of human malignancies such as prostate, lung, colon, gastric, and liver cancers. However, several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31901237
DOI: 10.1186/s12943-019-1124-x
PMCID: PMC6942384

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The emerging role of SPOP protein in tumorigenesis and cancer therapy.PMID 31901237Read ↗

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Opposing Roles of SPOP Mutations in Human Prostate and Endometrial Cancers.Semantic proximity Read ↗

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Higher-order SPOP assembly reveals a basis for cancer mutant dysregulation.Semantic proximity Read ↗

SPOP Gene Mutations in Prostate Cancer: Deciphering Their Role in Disease Characterization and Targeted Interventions on AR SignalingSemantic proximity Read ↗

Functional dissection of SPOP at the amino acid level reveals a comprehensive functional landscape of variants during tumorigenesis.Semantic proximity Read ↗

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