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Article

SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression

11 Jul 2018

Abstract excerpt

BACKGROUND: Next-generation sequencing of the exome and genome of prostate cancers has identified numerous genetic alterations. SPOP (Speckle-type POZ Protein) is one of the most frequently mutated genes in primary prostate cancer, suggesting that SPOP may be a potential driver of prostate cancer. The aim of this work was to investigate how SPOP mutations contribute to prostate cancer development and progression....

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PMID: 29996942
DOI: 10.1186/s13046-018-0809-0

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