Article
Opposing Roles of SPOP Mutations in Human Prostate and Endometrial Cancers.
JCO precision oncology - 1 Sept 2023
Cavalcante Ludimila, Deshmukh Sachin Kumar, Ribeiro Jennifer R, Carneiro Benedito A, Dizon Don S, Angara Kartik, Mattox Tyler, Wu Sharon, Xiu Joanne, Walker Phillip, Oberley Matthew, Nabhan Chadi, Huang Haojie, Antonarakis Emmanuel S
Abstract excerpt
PURPOSE: Recurrent gene mutations in speckle-type POZ protein (SPOP), the substrate-binding component of E3 ubiquitin ligase, are associated with tumor progression in prostate and endometrial cancers. Here, we characterized SPOP mutations in these cancers and explored their association with molecular and immune signatures and patient outcomes. METHODS: There were 7,398 prostate cancer and 19,188 endometrial...
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