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Article

Deregulation of SPOP in Cancer.

Cancer research - 15 Feb 2023

Zhang Hui, Jin Xiaofeng, Huang Haojie

Abstract excerpt

Speckle-type POZ protein (SPOP) is a substrate-binding adaptor of the CULLIN3/RING-box1 E3 ubiquitin ligase complex. SPOP is frequently mutated in prostate and endometrial cancers, whereas it is overexpressed in renal cell carcinoma (RCC). SPOP can mediate both degradable and nondegradable polyubiquitination of a number of substrates with diverse biological functions such as androgen receptor (AR), SRC-3, TRIM24,...

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Source

Identifiers

PMID: 36512624
DOI: 10.1158/0008-5472.CAN-22-2801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deregulation of SPOP in Cancer.PMID 36512624Read ↗

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Systematic Characterization of Cancer-Associated SPOP Mutants Reveals Novel and Reprogrammable Degradative Activities.Semantic proximity Read ↗

SPOP Gene Mutations in Prostate Cancer: Deciphering Their Role in Disease Characterization and Targeted Interventions on AR SignalingSemantic proximity Read ↗

The emerging role of speckle-type POZ protein (SPOP) in cancer development.Semantic proximity Read ↗

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