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Article

Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants.

Human mutation - 1 Sept 2014

Zhang Pingzhao, Gao Kun, Tang Yan, Jin Xiaofeng, An Jian, Yu Hongxiu, Wang Huan, Zhang Yuanyuan, Wang Dejie, Huang Haojie, Yu Long, Wang Chenji

Abstract excerpt

Characterization of the exome and genome of prostate cancers by next-generation sequencing has identified numerous genetic alternations. SPOP (speckle-type POZ protein) was identified as one of the most frequently affected genes by somatic point mutations in prostate cancer, suggesting SPOP is potentially a key driver for prostate cancer development and progression. However, how SPOP mutations contribute to...

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Source

Identifiers

PMID: 24990631
DOI: 10.1002/humu.22614

Genes

SPOP
DDIT3
CUL3
RBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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