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Article

G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer.

Nature communications - 18 Nov 2021

Mukhopadhyay Chandrani, Yang Chenyi, Xu Limei, Liu Deli, Wang Yu, Huang Dennis, Deonarine Lesa Dayal, Cyrta Joanna, Davicioni Elai, Sboner Andrea, Robinson Brian D, Chinnaiyan Arul M, Rubin Mark A, Barbieri Christopher E, Zhou Pengbo

Abstract excerpt

SPOP, an E3 ubiquitin ligase, acts as a prostate-specific tumor suppressor with several key substrates mediating oncogenic function. However, the mechanisms underlying SPOP regulation are largely unknown. Here, we have identified G3BP1 as an interactor of SPOP and functions as a competitive inhibitor of Cul3SPOP, suggesting a distinctive mode of Cul3SPOP inactivation in prostate cancer (PCa). Transcriptomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34795264
DOI: 10.1038/s41467-021-27024-x
PMCID: PMC8602290

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