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Article

TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

28 Dec 2015

Abstract excerpt

Cellular genomes are highly vulnerable to perturbations to chromosomal DNA replication. Proliferating cell nuclear antigen (PCNA), the processivity factor for DNA replication, plays a central role as a platform for recruitment of genome surveillance and DNA repair factors to replication forks, allowing cells to mitigate the threats to genome stability posed by replication stress. We identify the E3 ubiquitin...

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PMID: 26711499
DOI: 10.1083/jcb.201506071

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