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Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway

13 Oct 2008

Abstract excerpt

Failure to stabilize and properly process stalled replication forks results in chromosome instability, which is a hallmark of cancer cells and several human genetic conditions that are characterized by cancer predisposition. Loss of WRN, a RecQ-like enzyme mutated in the cancer-prone disease Werner syndrome (WS), leads to rapid accumulation of double-strand breaks (DSBs) and proliferating cell nuclear antigen...

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PMID: 18852298
DOI: 10.1083/jcb.200803173

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Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathwayPMID 18852298Read ↗

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrestSemantic proximity Read ↗

Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery.Semantic proximity Read ↗

Rad51 and Mitotic Function of Mus81 are Essential for Recovery from Low-Dose of Camptothecin in the Absence of the Wrn ExonucleaseSemantic proximity Read ↗

WRNIP1 prevents transcription-associated genomic instabilitySemantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

WRN helicase regulates the ATR–CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I–DNA covalent complexesSemantic proximity Read ↗

WRN as a Novel Target of Synthetic Lethality: Current Advances and Future PerspectivesSemantic proximity Read ↗

The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation.Semantic proximity Read ↗

The Drosophila Werner exonuclease participates in an exonuclease-independent response to replication stress.Semantic proximity Read ↗

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease.Semantic proximity Read ↗

Telomere dysfunction as a cause of genomic instability in Werner syndromeSemantic proximity Read ↗

Checkpoint defects require WRNIP1 to counteract R-loop-associated genomic instabilitySemantic proximity Read ↗

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