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CRISPR/Cas mediated disruption of BMPR-1B gene and introduction of FecB mutation into the Caprine embryos using Easi-CRISPR strategy.

Theriogenology - 1 Nov 2023

Jose Bosco, Punetha Meeti, Tripathi Manoj Kumar, Khanna Shivani, Yadav Vijay, Singh Amit Kumar, Kumar Brijesh, Singh Kiranjeet, Chouhan Vikrant Singh, Sarkar Mihir

Abstract excerpt

Bone Morphogenetic Proteins play a significant role in ovarian physiology and contribute to the reproductive fitness of mammals. The BMPR-1B/FecB mutation, a loss of function mutation increases litter size by 1-2 with each number of mutated alleles in sheep. Considering demand-supply gap of the meat industry, and low replacement rate of indigenous caprine species, the conservative BMPR-1B locus can be explored,...

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PMID: 37619525
DOI: 10.1016/j.theriogenology.2023.08.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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