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Article

CRISPR/Cas9-mediated specific integration of fat-1 at the goat MSTN locus.

The FEBS journal - 1 Aug 2018

Zhang Ju, Cui Meng-Lan, Nie Yong-Wei, Dai Bai, Li Fei-Ran, Liu Dong-Jun, Liang Hao, Cang Ming

Abstract excerpt

Recent advances in understanding the CRISPR/Cas9 system have provided a precise and versatile approach for genome editing in various species. However, no study has reported simultaneous knockout of endogenous genes and site-specific knockin of exogenous genes in large animal models. Using the CRISPR/Cas9 system, this study specifically inserted the fat-1 gene into the goat MSTN locus, thereby achieving...

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Source

Identifiers

PMID: 29802684
DOI: 10.1111/febs.14520

Genes

MSTN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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