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Rapid Genotyping of FecB Mutation in Sheep Using CRISPR-Cas12a Integrated with DNA Nanotree Biosensing Platform.

Biomolecules - 20 Feb 2025

Pan Dongxia, Mijit Mukaddas, Wang Hui, Sun Chaoqun, Pingcuo Bantan, Yu Zhixue, Xiong Benhai, Tang Xiangfang

Abstract excerpt

The A-to-G mutation (FecB) in the BMPR1B gene is strongly linked to fertility in sheep, significantly increasing ovulation rates and litter sizes compared to wild-type populations. The rapid and reliable screening of the FecB gene is therefore critical for advancing sheep breeding programs. This study aimed to develop a fast and accurate method for detecting the FecB mutation and genotyping the gene to enhance...

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Identifiers

PMID: 40149851
DOI: 10.3390/biom15030315
PMCID: PMC11940080

Genes

BMPR1B

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