Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline transmission of MSTN knockout cattle via CRISPR-Cas9.

Theriogenology - 15 Oct 2022

Gim Gyeong-Min, Uhm Kyeong-Hyun, Kwon Dong-Hyeok, Kim Min-Ji, Jung Dae-Jin, Kim Dae-Hyun, Yi Jun-Koo, Ha Jae-Jung, Yum Soo-Young, Son Woo-Jae, Lee Ji-Hyun, Park Ji-Hyun, Song Kil-Young, Lee Won-Wu, Jang Goo

Abstract excerpt

Although the production of several founder animals (F0) for gene editing in livestock has been reported in cattle, very few studies have assessed germline transmission to the next generation due to the long sexual maturation and gestation periods. The present study aimed to assess the germline transmission of MSTN mutations (-12bps deletion) in MSTN mutant F0 male and female cattle. For this purpose, oocytes and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cattle
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electroporation

Share to Gene Editing

Share to Mutation

Share to Myostatin

Share to Oocytes

Source

Identifiers

PMID: 36037573
DOI: 10.1016/j.theriogenology.2022.08.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline transmission of MSTN knockout cattle via CRISPR-Cas9.PMID 36037573Read ↗

Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system.Semantic proximity Read ↗

MSTN-edited born calves obtained by precision breeding, using CRISPR/Cas9 and SCNTSemantic proximity Read ↗

Cas9-expressing cattle using all-in-one CRISPR/Cas9 for bovine genome editingSemantic proximity Read ↗

Production of MSTN-mutated cattle without exogenous gene integration using CRISPR-Cas9.Semantic proximity Read ↗

Impact of CRISPR-Cas9-Based Genome Engineering in Farm AnimalsSemantic proximity Read ↗

One-Step Homology Mediated CRISPR-Cas Editing in Zygotes for Generating Genome Edited Cattle.Semantic proximity Read ↗

CRISPR/Cas9-mediated MSTN disruption and heritable mutagenesis in goats causes increased body mass.Semantic proximity Read ↗

NGS-based reverse genetic screen for common embryonic lethal mutations compromising fertility in livestock.Semantic proximity Read ↗

Efficient and Specific Generation of MSTN-Edited Hu Sheep Using C-CRISPR.Semantic proximity Read ↗

Evaluation of mutation rates, mosaicism and off target mutations when injecting Cas9 mRNA or protein for genome editing of bovine embryos.Semantic proximity Read ↗

CRISPR/Cas mediated disruption of BMPR-1B gene and introduction of FecB mutation into the Caprine embryos using Easi-CRISPR strategy.Semantic proximity Read ↗

Base pair editing of goat embryos: nonsense codon introgression into <i>FGF5</i> to improve cashmere yieldSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.