Article

Correction of a CFTR/G542X Mutation Using CRISPR/Cas9 Editing in Ovine-bovine Interspecies Embryos

2021-01-18

Abstract excerpt

Cystic fibrosis (CF) is a human genetic disease caused by mutations in the CF transmembrane conductance regulator ( CFTR ) gene. Correction of CFTR mutations at embryo stage could be a permanent solution to cure this disease. To assess the efficiency of CFTR /G542X mutation correction in vitro by CRISPR/Cas9, we utilized embryos generated by ovine-bovine interspecies somatic cell nuclear transfer (iSCNT) due to a...

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Literature Corpus work: 7480c54d-9866-5e19-98c8-45aeb00ffafb
DOI: 10.21203/rs.3.rs-140048/v1

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