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Introduction of the FecGF mutation in GDF9 gene via CRISPR/Cas9 system with single-stranded oligodeoxynucleotide.

Theriogenology - 1 Feb 2023

Xu Xin, Zhang Xuemei, Peng Xinrong, Liu Chunjie, Li Wenrong, Liu Mingjun

Abstract excerpt

The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) 9 system has been a recent focus of breeders owing to its potential to improve economically significant traits of livestock. The introduction of defined point mutations into the ovine genome via CRISPR/Cas9-mediated homology-directed repair has been reported; however, indel and mosaic events observed in genetically...

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PMID: 36525857
DOI: 10.1016/j.theriogenology.2022.11.044

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