Article
E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells.
The Journal of cell biology - 1 Jun 2020
Duan Haohui, Mansour Sarah, Reed Rachel, Gillis Margaret K, Parent Benjamin, Liu Ben, Sztupinszki Zsofia, Birkbak Nicolai, Szallasi Zoltan, Elia Andrew E H, Garber Judy E, Pathania Shailja
Abstract excerpt
BRCA1/2 help maintain genomic integrity by stabilizing stalled forks. Here, we identify the E3 ligase RFWD3 as an essential modulator of stalled fork stability in BRCA2-deficient cells and show that codepletion of RFWD3 rescues fork degradation, collapse, and cell sensitivity upon replication stress. Stalled forks in BRCA2-deficient cells accumulate phosphorylated and ubiquitinated replication protein A...
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