Back to search

Article

TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligases

2024-05-16

Abstract excerpt

Tripartite motif 52 (TRIM52) exhibits strong positive selection in humans, yet is lost in many other mammals. In contrast to what one would expect for such a non-conserved factor, TRIM52 loss compromises cell fitness. We set out to determine the cellular function of TRIM52. Genetic and proteomic analyses revealed TRIM52’s involvement in resolving topoisomerase 2 (TOP2)-DNA cross-links, mitigating DNA damage and p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
563ab3c9-3884-568b-b32a-d4656ab3c04a
DOI
10.1101/2024.05.16.594269
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligasesDOI 10.1101/2024.05.16.594269
TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligasesSemantic proximity
Trim33 masks a non-transcriptional function of E2f4 in replication fork progression.Semantic proximity
Trim45: An emerging E3 ubiquitin ligases in cancerSemantic proximity
TRIM family contribute to tumorigenesis, cancer development, and drug resistanceSemantic proximity
Expression and Role of TRIM2 in Human DiseasesSemantic proximity
Pan-cancer illumination of TRIM gene family reveals immunology regulation and potential therapeutic implications.Semantic proximity
Intricate confrontation: Research progress and application potential of TRIM family proteins in tumor immune escapeSemantic proximity
TRIM21: a multifaceted regulator in cancerSemantic proximity
Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary propertiesSemantic proximity
The complexity of TRIM28 contribution to cancerSemantic proximity
Emerging roles of TRIM27 in cancer and other human diseasesSemantic proximity
TRIM proteins and diseases.Semantic proximity
Select a neighboring publication to make it the new centre.