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TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases

24 Apr 2025

Abstract excerpt

Tripartite motif 52 (TRIM52) exhibits strong positive selection in humans, yet is lost in many other mammals. In contrast to what one would expect for such a non-conserved factor, TRIM52 loss compromises cell fitness. We set out to determine the cellular function of TRIM52. Genetic and proteomic analyses revealed TRIM52 physically and functionally interacts with the DNA repair machinery. Our data suggest that...

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PMID: 40274822
DOI: 10.1038/s41467-025-59129-y

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