Article
EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.
Molecular cell - 15 Jul 2021
Hambarde Shashank, Tsai Chi-Lin, Pandita Raj K, Bacolla Albino, Maitra Anirban, Charaka Vijay, Hunt Clayton R, Kumar Rakesh, Limbo Oliver, Le Meur Remy, Chazin Walter J, Tsutakawa Susan E, Russell Paul, Schlacher Katharina, Pandita Tej K, Tainer John A
Abstract excerpt
Stalled DNA replication fork restart after stress as orchestrated by ATR kinase, BLM helicase, and structure-specific nucleases enables replication, cell survival, and genome stability. Here we unveil human exonuclease V (EXO5) as an ATR-regulated DNA structure-specific nuclease and BLM partner for replication fork restart. We find that elevated EXO5 in tumors correlates with increased mutation loads and poor...
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