Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer's disease.

doi:10.1038/s41467-023-40775-z

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Article

Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimer's disease.

Nature communications - 23 Aug 2023

Langella Stephanie, Barksdale N Gil, Vasquez Daniel, Aguillon David, Chen Yinghua, Su Yi, Acosta-Baena Natalia, Acosta-Uribe Juliana, Baena Ana Y, Garcia-Ospina Gloria, Giraldo-Chica Margarita, Tirado Victoria, Muñoz Claudia, Ríos-Romenets Silvia, Guzman-Martínez Claudia, Oliveira Gabriel, Yang Hyun-Sik, Vila-Castelar Clara, Pruzin Jeremy J, Ghisays Valentina, Arboleda-Velasquez Joseph F, Kosik Kenneth S, Reiman Eric M, Lopera Francisco, Quiroz Yakeel T

Abstract excerpt

Autosomal dominant Alzheimer's disease (ADAD) is genetically determined, but variability in age of symptom onset suggests additional factors may influence cognitive trajectories. Although apolipoprotein E (APOE) genotype and educational attainment both influence dementia onset in sporadic AD, evidence for these effects in ADAD is limited. To investigate the effects of APOE and educational attainment on...

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PMID: 37612284
DOI: 10.1038/s41467-023-40775-z
PMCID: PMC10447560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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