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Article

Predicting Cognitive Decline across Four Decades in Mutation Carriers and Non-carriers in Autosomal-Dominant Alzheimer's Disease.

Journal of the International Neuropsychological Society : JINS - 1 Mar 2017

Almkvist Ove, Rodriguez-Vieitez Elena, Thordardottir Steinunn, Amberla Kaarina, Axelman Karin, Basun Hans, Kinhult-Ståhlbom Anne, Lilius Lena, Remes Anne, Wahlund Lars-Olof, Viitanen Matti, Lannfelt Lars, Graff Caroline

Abstract excerpt

OBJECTIVES: The aim of this study was to investigate cognitive performance including preclinical and clinical disease course in carriers and non-carriers of autosomal-dominant Alzheimer's disease (adAD) in relation to multiple predictors, that is, linear and non-linear estimates of years to expected clinical onset of disease, years of education and age. METHODS: Participants from five families with early-onset...

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Identifiers

PMID: 28079014
DOI: 10.1017/S1355617716001028

Genes

APP
PSEN1

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