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Article

Early-life educational attainment, APOE ε4 alleles, and incident dementia risk in late life.

GeroScience - 1 Jun 2022

Ma Hao, Zhou Tao, Li Xiang, Maraganore Demetrius, Heianza Yoriko, Qi Lu

Abstract excerpt

We examined the interactions between educational attainment and genetic susceptibility on dementia risk among adults over 60 years old. A total of 174,161 participants were free of dementia at baseline. The APOE ε4-related genetic risk was evaluated by the number of APOE ε4 alleles. The overall genetic susceptibility of dementia was evaluated by polygenetic risk score (PRS). Cox proportional hazards models were...

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Identifiers

PMID: 35306636
DOI: 10.1007/s11357-022-00545-z
PMCID: PMC9213617

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