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Article

APOE ε4 influences cognitive decline positively in APP and negatively in PSEN1 mutation carriers with autosomal-dominant Alzheimer's disease.

European journal of neurology - 1 Dec 2022

Almkvist Ove, Johansson Charlotte, Laffita-Mesa Jose, Thordardottir Steinunn, Graff Caroline

Abstract excerpt

BACKGROUND AND PURPOSE: The aim was to investigate the effect of APOE ε4 allele on cognitive decline in adAD. Presence of the APOE ε4 allele reduces age of symptom onset, increases disease progression, and lowers cognitive performance in sporadic Alzheimer's disease (AD), while the impact of the APOE ε4 allele in autosomal-dominant AD (adAD) is incompletely known. METHODS: Mutation carriers (MCs; n = 39) and...

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Identifiers

PMID: 36039401
DOI: 10.1111/ene.15536
PMCID: PMC9826049

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