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Cognitive performance protects against Alzheimer's disease independently of educational attainment and intelligence.

Molecular psychiatry - 1 Oct 2022

Hu Yang, Zhang Yan, Zhang Haihua, Gao Shan, Wang Longcai, Wang Tao, Han Zhifa, Sun Bao-Liang, Liu Guiyou

Abstract excerpt

Mendelian-randomization (MR) studies using large-scale genome-wide association studies (GWAS) have identified causal association between educational attainment and Alzheimer's disease (AD). However, the underlying mechanisms are still required to be explored. Here, we conduct univariable and multivariable MR analyses using large-scale educational attainment, cognitive performance, intelligence and AD GWAS...

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Alzheimer Disease
Cognition
Dementia and Cognitive Impairment Research
Educational Status
Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Polymorphism, Single Nucleotide

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PMID: 35840796
DOI: 10.1038/s41380-022-01695-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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