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Article

Heterogeneity of HSCs in a Mouse Model of NASH.

Hepatology (Baltimore, Md.) - 1 Aug 2021

Rosenthal Sara Brin, Liu Xiao, Ganguly Souradipta, Dhar Debanjan, Pasillas Martina P, Ricciardelli Eugenia, Li Rick Z, Troutman Ty D, Kisseleva Tatiana, Glass Christopher K, Brenner David A

Abstract excerpt

BACKGROUND AND AIMS: In clinical and experimental NASH, the origin of the scar-forming myofibroblast is the HSC. We used foz/foz mice on a Western diet to characterize in detail the phenotypic changes of HSCs in a NASH model. APPROACH AND RESULTS: We examined the single-cell expression profiles (scRNA sequencing) of HSCs purified from the normal livers of foz/foz mice on a chow diet, in NASH with fibrosis of...

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Identifiers

PMID: 33550587
DOI: 10.1002/hep.31743
PMCID: PMC8346581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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