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Article

Perturbation of Specific Signaling Pathways Is Involved in Initiation of Mouse Liver Fibrosis.

Hepatology (Baltimore, Md.) - 1 Apr 2021

Chen Liping, Guo Ping, Li Wenxue, Fang Fei, Zhu Wei, Fan Junling, Wang Fangping, Gao Yuanyuan, Zhao Qun, Wang Qing, Xiao Yongmei, Xing Xiumei, Li Daochuan, Shi Tieliu, Yu Dianke, Aschner Michael, Zhang Lihua, Chen Wen

Abstract excerpt

BACKGROUND AND AIMS: To identify the regulatory role of protein phosphatase 2A (PP2A) in the development of liver disease, we generated a mouse model with hepatocyte-specific deletion of Ppp2r1a gene (encoding PP2A Aα subunit). APPROACH AND RESULTS: Homozygote (HO) mice and matched wild-type littermates were investigated at 3, 6, 9, 12, 15, and 18 months of age. Pathological examination showed that PP2A Aα...

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Identifiers

PMID: 32654205
DOI: 10.1002/hep.31457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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