The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice.

doi:10.1016/j.jcmgh.2020.08.010

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Article

The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice.

Cellular and molecular gastroenterology and hepatology - 1 Jan 2021

Tuominen Iina, Fuqua Brie K, Pan Calvin, Renaud Nicole, Wroblewski Kevin, Civelek Mete, Clerkin Kara, Asaryan Ashot, Haroutunian Sara G, Loureiro Joseph, Borawski Jason, Roma Guglielmo, Knehr Judith, Carbone Walter, French Samuel, Parks Brian W, Hui Simon T, Mehrabian Margarete, Magyar Clara, Cantor Rita M, Ukomadu Chinweike, Lusis Aldons J, Beaven Simon W

Abstract excerpt

BACKGROUND & AIMS: Liver fibrosis is a multifactorial trait that develops in response to chronic liver injury. Our aim was to characterize the genetic architecture of carbon tetrachloride (CCl4)-induced liver fibrosis using the Hybrid Mouse Diversity Panel, a panel of more than 100 genetically distinct mouse strains optimized for genome-wide association studies and systems genetics. METHODS: Chronic liver injury...

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Identifiers

PMID: 32866618
DOI: 10.1016/j.jcmgh.2020.08.010
PMCID: PMC7674618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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