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Article

Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis.

Gastroenterology - 1 Sept 2015

Sendler Matthias, Beyer Georg, Mahajan Ujjwal M, Kauschke Vivien, Maertin Sandrina, Schurmann Claudia, Homuth Georg, Völker Uwe, Völzke Henry, Halangk Walter, Wartmann Thomas, Weiss Frank-Ulrich, Hegyi Peter, Lerch Markus M, Mayerle Julia

Abstract excerpt

BACKGROUND & AIMS: Little is known about the pathogenic mechanisms of chronic pancreatitis. We investigated the roles of complement component 5 (C5) in pancreatic fibrogenesis in mice and patients. METHODS: Chronic pancreatitis was induced by ligation of the midpancreatic duct, followed by a single supramaximal intraperitoneal injection of cerulein, in C57Bl6 (control) and C5-deficient mice. Some mice were given...

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Identifiers

PMID: 26001927
DOI: 10.1053/j.gastro.2015.05.012
PMCID: PMC4560830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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