Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice

16 Jun 2018

Abstract excerpt

We report the genetic analysis of a "humanized" hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis. Mice carrying transgenes for human apolipoprotein E*3-Leiden and cholesteryl ester transfer protein and fed a "Western" diet were studied on the genetic backgrounds of over 100 inbred mouse strains. The mice developed hepatic inflammation and fibrosis that was highly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Associations and Epidemiology
Share to Lipid metabolism and disorders
Share to Liver Disease Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29907965
DOI: 10.1002/hep.30113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in MicePMID 29907965Read ↗

The genetic architecture of NAFLD among inbred strains of miceSemantic proximity Read ↗

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progressionSemantic proximity Read ↗

Genetics of liver injury and fibrosis.Semantic proximity Read ↗

Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis.Semantic proximity Read ↗

Common transcriptional programme of liver fibrosis in mouse genetic models and humansSemantic proximity Read ↗

Genetics of Nonalcoholic Fatty Liver Disease: From Pathogenesis to TherapeuticsSemantic proximity Read ↗

Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease.Semantic proximity Read ↗

How Useful Are Monogenic Rodent Models for the Study of Human Non-Alcoholic Fatty Liver Disease?Semantic proximity Read ↗

The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver DiseaseSemantic proximity Read ↗

Longitudinal analysis of a dietary mouse model of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)Semantic proximity Read ↗

Proteome-wide QTL mapping enables gene-protein-phenotype metabolic network construction in a genetically diverse MASLD mouse modelSemantic proximity Read ↗

Spatio-Temporal Multiscale Analysis of Western Diet-Fed Mice Reveals a Translationally Relevant Sequence of Events during NAFLD ProgressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.