Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagy

22 Aug 2023

Abstract excerpt

Accumulating evidence has shown that the quality of proteins must be tightly monitored and controlled to maintain cellular proteostasis. Misfolded proteins and protein aggregates are targeted for degradation through the ubiquitin proteasome (UPS) and autophagy-lysosome systems. The ubiquitination and deubiquitinating enzymes (DUBs) have been reported to play pivotal roles in the regulation of the UPS system....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37607937
DOI: 10.1038/s41419-023-06062-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The deubiquitinase Leon/USP5 interacts with Atg1/ULK1 and antagonizes autophagyPMID 37607937Read ↗

The deubiquitinase Leon/USP5 regulates ubiquitin homeostasis during Drosophila development.Semantic proximity Read ↗

The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins.Semantic proximity Read ↗

ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer CellsSemantic proximity Read ↗

USP14 inhibition enhances Parkin-independent mitophagy in iNeuronsSemantic proximity Read ↗

A neuroprotective role of Ufmylation through Atg9 in the aging brain of DrosophilaSemantic proximity Read ↗

Pharmacological inhibition of USP14 delays proteostasis-associated aging in a proteasome-dependent but foxo-independent mannerSemantic proximity Read ↗

Proteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substratesSemantic proximity Read ↗

USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5Semantic proximity Read ↗

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.Semantic proximity Read ↗

The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.Semantic proximity Read ↗

Synthetic Quantitative Array Technology Identifies the Ubp3-Bre5 Deubiquitinase Complex as a Negative Regulator of MitophagySemantic proximity Read ↗

USP8 inhibition regulates autophagy flux and controls Salmonella infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.