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Article

The deubiquitinase Leon/USP5 regulates ubiquitin homeostasis during Drosophila development.

Biochemical and biophysical research communications - 26 Sept 2014

Wang Chien-Hsiang, Chen Guang-Chao, Chien Cheng-Ting

Abstract excerpt

Ubiquitination and the reverse process deubiquitination regulate protein stability and function during animal development. The Drosophila USP5 homolog Leon functions as other family members of unconventional deubiquitinases, disassembling free, substrate-unconjugated polyubiquitin chains to replenish the pool of mono-ubiquitin, and maintaining cellular ubiquitin homeostasis. However, the significance of Leon/USP5...

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Identifiers

PMID: 25152394
DOI: 10.1016/j.bbrc.2014.08.069

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USP5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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