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USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5

1 Apr 2019

Abstract excerpt

Embryonic stem cells (ESCs) can propagate in an undifferentiated state indefinitely in culture and retain the potential to differentiate into any somatic lineage as well as germ cells. The catabolic process autophagy has been reported to be involved in ESC identity regulation, but the underlying mechanism is still largely unknown. Here we show that EPG5, a eukaryotic-specific autophagy regulator which mediates...

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PMID: 30931944
DOI: 10.1038/s41467-019-09430-4

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