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Article

The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.

Molecular cell - 19 May 2016

Joo Joung Hyuck, Wang Bo, Frankel Elisa, Ge Liang, Xu Lu, Iyengar Rekha, Li-Harms XiuJie, Wright Christopher, Shaw Timothy I, Lindsten Tullia, Green Douglas R, Peng Junmin, Hendershot Linda M, Kilic Fusun, Sze Ji Ying, Audhya Anjon, Kundu Mondira

Abstract excerpt

ULK1 and ULK2 are thought to be essential for initiating autophagy, and Ulk1/2-deficient mice die perinatally of autophagy-related defects. Therefore, we used a conditional knockout approach to investigate the roles of ULK1/2 in the brain. Although the mice showed neuronal degeneration, the neurons showed no accumulation of P62(+)/ubiquitin(+) inclusions or abnormal membranous structures, which are observed in...

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Source

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Identifiers

PMID: 27203176
DOI: 10.1016/j.molcel.2016.04.020
PMCID: PMC4993601

Genes

ULK1
ATG13
ULK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.PMID 27203176Read ↗

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