Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy.

doi:10.1016/j.celrep.2021.109410

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Article

Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy.

Cell reports - 20 Jul 2021

Terranova Christopher J, Tang Ming, Maitituoheti Mayinuer, Raman Ayush T, Ghosh Archit K, Schulz Jonathan, Amin Samir B, Orouji Elias, Tomczak Katarzyna, Sarkar Sharmistha, Oba Junna, Creasy Caitlin, Wu Chang-Jiun, Khan Samia, Lazcano Rossana, Wani Khalida, Singh Anand, Barrodia Praveen, Zhao Dongyu, Chen Kaifu, Haydu Lauren E, Wang Wei-Lien, Lazar Alexander J, Woodman Scott E, Bernatchez Chantale, Rai Kunal

Abstract excerpt

The dynamic evolution of chromatin state patterns during metastasis, their relationship with bona fide genetic drivers, and their therapeutic vulnerabilities are not completely understood. Combinatorial chromatin state profiling of 46 melanoma samples reveals an association of NRAS mutants with bivalent histone H3 lysine 27 trimethylation (H3K27me3) and Polycomb repressive complex 2. Reprogramming of bivalent...

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PMID: 34289358
DOI: 10.1016/j.celrep.2021.109410
PMCID: PMC8369408

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