Article
The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.
Nature communications - 22 Jan 2015
Zingg Daniel, Debbache Julien, Schaefer Simon M, Tuncer Eylul, Frommel Sandra C, Cheng Phil, Arenas-Ramirez Natalia, Haeusel Jessica, Zhang Yudong, Bonalli Mario, McCabe Michael T, Creasy Caretha L, Levesque Mitchell P, Boyman Onur, Santoro Raffaella, Shakhova Olga, Dummer Reinhard, Sommer Lukas
Abstract excerpt
Increased activity of the epigenetic modifier EZH2 has been associated with different cancers. However, evidence for a functional role of EZH2 in tumorigenesis in vivo remains poor, in particular in metastasizing solid cancers. Here we reveal central roles of EZH2 in promoting growth and metastasis of cutaneous melanoma. In a melanoma mouse model, conditional Ezh2 ablation as much as treatment with the...
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