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Article

MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cells

2 Dec 2022

Abstract excerpt

MacroH2A variants have been linked to inhibition of metastasis through incompletely understood mechanisms. Here, we reveal that solitary dormant disseminated cancer cells (DCCs) display increased levels of macroH2A variants in head and neck squamous cell carcinoma PDX in vivo models and patient samples compared to proliferating primary or metastatic lesions. We demonstrate that dormancy-inducing transforming...

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PMID: 36459552
DOI: 10.1126/sciadv.abo0876

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