Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.

doi:10.1126/scitranslmed.3003155

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Article

Novel adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man.

Science translational medicine - 4 Jan 2012

Barnes Eleanor, Folgori Antonella, Capone Stefania, Swadling Leo, Aston Stephen, Kurioka Ayako, Meyer Joel, Huddart Rachel, Smith Kira, Townsend Rachel, Brown Anthony, Antrobus Richard, Ammendola Virginia, Naddeo Mariarosaria, O'Hara Geraldine, Willberg Chris, Harrison Abby, Grazioli Fabiana, Esposito Maria Luisa, Siani Loredana, Traboni Cinzia, Oo Ye, Adams David, Hill Adrian, Colloca Stefano, Nicosia Alfredo, Cortese Riccardo, Klenerman Paul

Abstract excerpt

Currently, no vaccine exists for hepatitis C virus (HCV), a major pathogen thought to infect 170 million people globally. Many studies suggest that host T cell responses are critical for spontaneous resolution of disease, and preclinical studies have indicated a requirement for T cells in protection against challenge. We aimed to elicit HCV-specific T cells with the potential for protection using a recombinant...

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Identifiers

PMID: 22218690
DOI: 10.1126/scitranslmed.3003155
PMCID: PMC3627207

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