Article

Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals

2024-02-09

Abstract excerpt

<h4>SUMMARY</h4> Immunization with mosaic-8b [60-mer nanoparticles presenting 8 SARS-like betacoronavirus (sarbecovirus) receptor-binding domains (RBDs)] elicits more broadly cross-reactive antibodies than homotypic SARS-CoV-2 RBD-only nanoparticles and protects against sarbecoviruses. To investigate original antigenic sin (OAS) effects on mosaic-8b efficacy, we evaluated effects of prior COVID-19 vaccinations in...

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Identifiers and source

Literature Corpus work: 023a1e13-88eb-5b58-9e23-33110513bd1f
DOI: 10.1101/2024.02.08.576722

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