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Article

A pan-genotype hepatitis C virus viral vector vaccine generates T cells and neutralizing antibodies in mice.

Hepatology (Baltimore, Md.) - 1 Oct 2022

Donnison Timothy, McGregor Joey, Chinnakannan Senthil, Hutchings Claire, Center Rob J, Poumbourios Pantelis, Klenerman Paul, Drummer Heidi E, Barnes Eleanor

Abstract excerpt

BACKGROUND AND AIMS: A prophylactic vaccine targeting multiple HCV genotypes (gt) is urgently required to meet World Health Organization elimination targets. Neutralizing antibodies (nAbs) and CD4+ and CD8+ T cells are associated with spontaneous clearance of HCV, and each may contribute to protective immunity. However, current vaccine candidates generate either nAbs or T cells targeting genetically variable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35313015
DOI: 10.1002/hep.32470
PMCID: PMC9790311

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