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Article

Alphavirus vector-based replicon particles expressing multivalent cross-protective Lassa virus glycoproteins

26 Dec 2017

Abstract excerpt

Lassa virus (LASV) is the most prevalent rodent-borne arenavirus circulated in West Africa. With population at risk from Senegal to Nigeria, LASV causes Lassa fever and is responsible for thousands of deaths annually. High genetic diversity of LASV is one of the challenges for vaccine R&D. We developed multivalent virus-like particle vectors (VLPVs) derived from the human Venezuelan equine encephalitis TC-83 IND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29287681
DOI: 10.1016/j.vaccine.2017.12.046

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