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Unraveling the Complex Story of Immune Responses to AAV Vectors Trial After Trial

24 Aug 2017

Abstract excerpt

Over the past decade, vectors derived from adeno-associated virus (AAV) have established themselves as a powerful tool for in vivo gene transfer, allowing long-lasting and safe transgene expression in a variety of human tissues. Nevertheless, clinical trials demonstrated how B and T cell immune responses directed against the AAV capsid, likely arising after natural infection with wild-type AAV, might potentially...

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PMID: 28835127
DOI: 10.1089/hum.2017.150

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