Article
Efficient immunization of rhesus macaques with an HCV candidate vaccine by heterologous priming-boosting with novel adenoviral vectors based on different serotypes.
Gene therapy - 1 Jul 2006
Fattori E, Zampaglione I, Arcuri M, Meola A, Ercole B B, Cirillo A, Folgori A, Bett A, Cappelletti M, Sporeno E, Cortese R, Nicosia A, Colloca S
Abstract excerpt
Efficient vaccination against viral agents requires a strong T-cell-mediated immune response to clear viral-infected cells. Optimal vaccination can be achieved by administration of recombinant viral vectors encoding phatogen antigens. Adenoviral vectors have attracted considerable attention as potential viral vectors for genetic vaccination owing to their favorable safety profile and potent transduction...
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