Article
Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine.
Human vaccines & immunotherapeutics - 1 Jan 2014
Latimer Brian, Toporovski Roberta, Yan Jian, Pankhong Panyupa, Morrow Matthew P, Khan Amir S, Sardesai Niranjan Y, Welles Seth L, Jacobson Jeffrey M, Weiner David B, Kutzler Michele A
Abstract excerpt
Chronic HCV is a surreptitious disease currently affecting approximately 3% of the world's population that can lead to liver failure and cancer decades following initial infection. However, there are currently no vaccines available for the prevention of chronic HCV. From patients who acutely resolve HCV infection, it is apparent that a strong and broad cytotoxic T lymphocyte (CTL) response is important in HCV...
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