Article
The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes.
Vaccine - 4 Jan 2018
von Delft Annette, Donnison Timothy A, Lourenço José, Hutchings Claire, Mullarkey Caitlin E, Brown Anthony, Pybus Oliver G, Klenerman Paul, Chinnakannan Senthil, Barnes Eleanor
Abstract excerpt
BACKGROUND: Hepatitis C virus (HCV) genomic variability is a major challenge to the generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell responses induced by a potent T-cell vaccine encoding a single strain subtype-1b immunogen target epitopes dominant in natural infection. However, corresponding viral regions are highly variable at a population level, with a reduction in T-cell...
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