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Article

Polygenic risk score-based phenome-wide association study of head and neck cancer across two large biobanks.

BMC medicine - 14 Mar 2024

Lee Young Chan, Jung Sang-Hyuk, Shivakumar Manu, Cha Soojin, Park Woong-Yang, Won Hong-Hee, Eun Young-Gyu, Biobank Penn Medicine, Kim Dokyoon

Abstract excerpt

BACKGROUND: Numerous observational studies have highlighted associations of genetic predisposition of head and neck squamous cell carcinoma (HNSCC) with diverse risk factors, but these findings are constrained by design limitations of observational studies. In this study, we utilized a phenome-wide association study (PheWAS) approach, incorporating a polygenic risk score (PRS) derived from a wide array of genomic...

Topics

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Biological Specimen Banks
Genetic Associations and Epidemiology
Genetic Predisposition to Disease
Genetic Risk Score
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Head and Neck Cancer Studies

Head and Neck Neoplasms

Squamous Cell Carcinoma of Head and Neck

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Open in PubMed Open full text

Identifiers

PMID: 38486201
DOI: 10.1186/s12916-024-03305-2
PMCID: PMC10941505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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