Article
Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians.
Biological research - 13 Aug 2023
Piccardi Margherita, Gentiluomo Manuel, Bertoncini Stefania, Pezzilli Raffaele, Erőss Bálint, Bunduc Stefania, Uzunoglu Faik G, Talar-Wojnarowska Renata, Vanagas Tomas, Sperti Cosimo, Oliverius Martin, Aoki Mateus Nóbrega, Ermini Stefano, Hussein Tamás, Boggi Ugo, Jamroziak Krzysztof, Maiello Evaristo, Morelli Luca, Vodickova Ludmila, Di Franco Gregorio, Landi Stefano, Szentesi Andrea, Lovecek Martin, Puzzono Marta, Tavano Francesca, van Laarhoven Hanneke W M, Zerbi Alessandro, Mohelnikova-Duchonova Beatrice, Stocker Hannah, Costello Eithne, Capurso Gabriele, Ginocchi Laura, Lawlor Rita T, Vanella Giuseppe, Bazzocchi Francesca, Izbicki Jakob R, Latiano Anna, Bueno-de-Mesquita Bas, Ponz de Leon Pisani Ruggero, Schöttker Ben, Soucek Pavel, Hegyi Péter, Gazouli Maria, Hackert Thilo, Kupcinskas Juozas, Poskiene Lina, Tacelli Matteo, Roth Susanne, Carrara Silvia, Perri Francesco, Hlavac Viktor, Theodoropoulos George E, Busch Olivier R, Mambrini Andrea, van Eijck Casper H J, Arcidiacono Paolo, Scarpa Aldo, Pasquali Claudio, Basso Daniela, Lucchesi Maurizio, Milanetto Anna Caterina, Neoptolemos John P, Cavestro Giulia Martina, Janciauskas Dainius, Chen Xuechen, Chammas Roger, Goetz Mara, Brenner Hermann, Archibugi Livia, Dannemann Michael, Canzian Federico, Tofanelli Sergio, Campa Daniele
Abstract excerpt
BACKGROUND: The genomes of present-day non-Africans are composed of 1-3% of Neandertal-derived DNA as a consequence of admixture events between Neandertals and anatomically modern humans about 50-60 thousand years ago. Neandertal-introgressed single nucleotide polymorphisms (aSNPs) have been associated with modern human disease-related traits, which are risk factors for pancreatic ductal adenocarcinoma (PDAC),...
Read the complete abstract on PubMed