Article
Genome-wide association study identifies an early onset pancreatic cancer risk locus.
International journal of cancer - 15 Oct 2020
Campa Daniele, Gentiluomo Manuel, Obazee Ofure, Ballerini Alba, Vodickova Ludmila, Hegyi Péter, Soucek Pavel, Brenner Hermann, Milanetto Anna Caterina, Landi Stefano, Gao Xin, Bozzato Dania, Capurso Gabriele, Tavano Francesca, Vashist Yogesh, Hackert Thilo, Bambi Franco, Bursi Simona, Oliverius Martin, Gioffreda Domenica, Schöttker Ben, Ivanauskas Audrius, Mohelnikova-Duchonova Beatrice, Darvasi Erika, Pezzilli Raffaele, Małecka-Panas Ewa, Strobel Oliver, Gazouli Maria, Katzke Verena, Szentesi Andrea, Cavestro Giulia Martina, Farkas Gyula, Izbicki Jakob R, Moz Stefania, Archibugi Livia, Hlavac Viktor, Vincze Áron, Talar-Wojnarowska Renata, Rusev Borislav, Kupcinskas Juozas, Greenhalf Bill, Dijk Frederike, Giese Nathalia, Boggi Ugo, Andriulli Angelo, Busch Olivier R, Vanella Giuseppe, Vodicka Pavel, Nentwich Michael, Lawlor Rita T, Theodoropoulos George E, Jamroziak Krzysztof, Zuppardo Raffaella Alessia, Moletta Lucia, Ginocchi Laura, Kaaks Rudolf, Neoptolemos John P, Lucchesi Maurizio, Canzian Federico
Abstract excerpt
Early onset pancreatic cancer (EOPC) is a rare disease with a very high mortality rate. Almost nothing is known on the genetic susceptibility of EOPC, therefore, we performed a genome-wide association study (GWAS) to identify novel genetic variants specific for patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) at younger ages. In the first phase, conducted on 821 cases with age of onset ≤60 years,...
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